REBLOZYL® (luspatercept-aamt) is a prescription medicine used to treat anemia (low red blood cells) without previous erythropoiesis stimulating agent use (ESA-naïve) in adult patients with very low- to intermediate-risk myelodysplastic syndromes (MDS) who may require regular red blood cell (RBC) transfusions.
It is not known if REBLOZYL is safe or effective in children under 18 years of age.
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REBLOZYL is an injection given under your skin by your healthcare team at their office
You will receive a REBLOZYL injection once every 3 weeks. Before each REBLOZYL injection, your healthcare team will:
Do a blood test to check your hemoglobin (Hgb) levels
Discuss the number of transfusions you’ve had since your last REBLOZYL dose
Your healthcare team may also talk about any symptoms you’ve been having. This information helps your healthcare team see how your anemia
is responding to REBLOZYL. It’s important to talk about how you’re feeling with your healthcare team to help them understand how you’re doing and if you’re meeting your treatment goals.
Length of treatment
Length of treatment
The length of treatment varies from person to person. As part of ongoing treatment, your doctor may adjust the dose from time to time. You’ll stay on treatment with REBLOZYL for as long as you are responding to it and your side effects are manageable.
Starting dose
Starting dose
Your doctor will decide what dose of REBLOZYL is right for you based on your weight. It is recommended that people receiving REBLOZYL start on 1 milligram (mg)/kilogram (kg),
once every 3 weeks. Your dose may go up. You and your healthcare team can work together to see what REBLOZYL dose works for you.
Finding the right dose
Finding the right dose
Based on how REBLOZYL was studied, many patients experienced at least one dose modification. An increase in your dose of REBLOZYL does not necessarily mean REBLOZYL isn’t working for you. You may actually just need a higher dose to get the response you and your healthcare team are looking for. That’s why it can be helpful to be aware of your dose and to track your symptoms and any transfusions you need between doses.
You may want to write down when you receive red blood cell (RBC) transfusions and any symptoms you feel between doses of REBLOZYL.
Understanding your transfusion burden will help your healthcare team understand if you need an increase in dose to meet your treatment goals.