Starting a new medicine is not something to be taken lightly. You may feel uncertain at first. Knowing how REBLOZYL has impacted other people can help you understand why your doctor
Starting a new medicine is not something to be taken lightly. You may feel uncertain at first. Knowing how REBLOZYL has impacted other people can help you understand why your doctor
The main goal of the study was to see if REBLOZYL could lower the number of transfusions
needed by at least one-third during a set 12-week period compared to placebo.* People in both treatment groups were allowed to receive best supportive care. This included red blood cell (RBC) transfusions, iron-chelating agents, use of antibiotic, antiviral and antifungal therapy or nutritional support, as needed.
*Set 12-week period was weeks 13–24.
Percentage of people who
over 12 weeks of treatment
which means that
4x greater percentage of patients receiving REBLOZYL reduced their transfusion burden vs placebo
While on REBLOZYL, you may lower the number of transfusions needed, which can look different from person to person. This is why it’s so important to talk about your treatment goals with your healthcare team. Together, you can make sure you’re tracking toward the same expectation.
Example patient: What this might look like
For example, if a patient needed 6 RBC units every 12 weeks before starting REBLOZYL…
…this patient may only need 4 (or less) RBC units during weeks 13 to 24 after starting REBLOZYL
Everyone in the study regularly received 6 to 20 units of packed RBCs and had not been transfusion-free for more than 35 days within 24 weeks before the study started
Patients could not be a part of the study if they were under 18 or had:
S/BT or alpha (α)-thalassemia immunosuppressant, or hydroxyurea therapyIt’s important to know about the possible side effects of REBLOZYL before beginning treatment. Remember: people may react to medicines differently, and that’s expected.
The possible side effects of REBLOZYL are well-known. Be sure to talk with your healthcare team about what to expect when starting treatment with REBLOZYL.
Blood clots (thrombosis/thromboembolism)
Blood clots in the arteries, veins, brain, and lungs have happened in people with BT during treatment with REBLOZYL. The risk of blood clots may be higher in people who have had their spleen removed or who take
Call your healthcare provider or get medical help right away if you have any of these symptoms:
High blood pressure (hypertension)
REBLOZYL may cause an increase in your blood pressure. Your healthcare provider will check your blood pressure before you receive your REBLOZYL dose. Your healthcare provider may prescribe you medicine to treat high blood pressure or increase the dose of medicine you already take to treat high blood pressure, if you develop high blood pressure during treatment with REBLOZYL.
Extramedullary Hematopoietic (EMH) Masses
EMH masses have happened in people with beta thalassemia during treatment with REBLOZYL. You may have a higher risk for developing EMH masses if you have a history of EMH masses, have had your spleen removed, have or have had enlarged spleen or liver, or have low hemoglobin levels. Your healthcare provider will monitor you before you start and during treatment with REBLOZYL. Call your healthcare provider or get medical help right away if you get any of these symptoms:
Most common side effects
The most common side effects are the side effects that were the most frequently reported by patients in the study. You may experience more than one side effect at the same time.
The most common side effects of REBLOZYL include:
These are not all of the possible side effects. For more information about side effects, please see the REBLOZYL Patient Information.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
