REBLOZYL® (luspatercept-aamt) logo
Now approved for earlier treatment of MDS-related anemia badge


REBLOZYL® (luspatercept-aamt) is a prescription medicine used to treat anemia (low red blood cells) without previous erythropoiesis stimulating agent use (ESA-naïve) in adult patients with very low- to intermediate-risk myelodysplastic syndromes (MDS) who may require regular red blood cell (RBC) transfusions.

It is not known if REBLOZYL is safe or effective in children under 18 years of age.

This website is best viewed using the horizontal display on your tablet device.

This website is best viewed using the vertical display on your mobile device.

Anemia plays a role in beta (β) thalassemia (BT)

Anemia is one of the most common symptoms of BT and one that you may feel the most. Your anemia may make you feel tired or weak and can impact your ability to do everyday tasks and activities. It can also have long-term impacts on your health and well-being.

How does anemia in BT happen?

Anemia is a condition where you don’t have enough healthy red blood cells (RBC). This means your blood has lower than normal hemoglobin (Hgb) levels. Hgb is an important part of an RBC. It is the part of the cell that brings oxygen to your body and organs.

Immature red blood cell developing into a mature red blood cell

In BT, ineffective erythropoiesis (IE) leads to RBCs piling up in your bone marrow. You can learn more about IE here.

Immature red blood cells piling up in bone marrow and unable to enter the bloodstream to do their job

RBCs pile up when they are not able to fully mature and enter the bloodstream to do their job. This can lead to your body making too few mature, working RBCs that also may not live as long. This can lead to anemia.

Bloodstream Bloodstream

You may require more or fewer RBC transfusions depending on the severity of your BT. If you have questions about this, be sure to talk to your healthcare team. They can help you identify next steps and potential treatment options.

What are the possible symptoms of anemia associated with BT?

Common symptoms of anemia include:

  • Problems with thinking or memory
  • Feeling tired
  • Weakness
  • Dizziness
  • Lightheadedness
  • Headaches
  • Shortness of breath

There are also effects of anemia associated with BT that you may not be able to see. These include:

  • Enlarged spleen
  • Brittle bones, meaning they can break easily
  • Rapid or irregular heartbeat or stroke
  • Complications from iron overload

Explore how REBLOZYL can help with anemia due to BT.

Hypothetical patient with anemia in beta thalassemia (BT)

Why does anemia in BT matter?

People living with BT experience anemia. This can impact life now, and in the future. Some symptoms may be easily seen or felt, while others aren’t as obvious.

Anemia can have an impact on your daily life and affect your overall health. Living with anemia symptoms can be frustrating and discouraging. They can get in the way of your daily activities. You may feel too tired to go to the store or too weak to complete your usual tasks.

Having anemia can also cause problems over time and may impact your future health. When anemia is not treated, it can have negative impacts on your organs. It may affect how well your intestines, heart, and lungs work. It can even cause your spleen to become enlarged, which may mean you need to have your spleen removed through surgery. This is called a splenectomy.

This may be alarming to hear. That’s why paying attention to new and changing symptoms of anemia is an important part of managing BT.