REBLOZYL® (luspatercept-aamt) is a prescription medicine used to treat anemia (low red blood cells) in adults with beta thalassemia who need regular red blood cell (RBC) transfusions.
REBLOZYL is not for use as a substitute for RBC transfusions in people who need immediate treatment for anemia.
It is not known if REBLOZYL is safe or effective in children.
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Alpha globin: One of two protein building blocks of hemoglobin
Anemia: Low red blood cell (RBC) count
Beta (β) globin: One of two protein building blocks of hemoglobin
Beta (β) thalassemia (BT): A blood disorder where your body makes less hemoglobin than normal
Blood pressure: The force of circulating blood on the walls of blood vessels
Bone marrow: The soft interior of the bones where new blood cells are created
Chelation therapy: A chemical compound used to remove toxic metals from the body
Erythroid cells: An immature red blood cell
Erythroid maturation agent (EMA): Treatment that helps red blood cells to mature
Erythropoiesis: The formation of red blood cells in blood-forming tissue within the bone marrow
Extramedullary hematopoiesis (EMH): When blood cells form outside of the bone marrow
Gene: The physical or mental traits that are passed down from parent to child
Hemoglobin (Hgb): Oxygen-carrying protein found in red blood cells
Hormone: A chemical made by your body that travels in the bloodstream to send messages throughout your body
Hydroxyurea: A type of medicine used to treat certain cancers
Immunosuppressant: An agent that decreases the body’s immune response
Ineffective erythropoiesis (IE): The inability of immature red blood cells to become mature
Kilogram (kg): A unit for measuring your weight. One kg is 2.2 pounds
Milligram (mg): A unit for measuring weight
mg/kg: The dose of your medication based on your body weight
Placebo: An inactive substance that looks the same as, and is given the same way as, an active drug or treatment being tested
Protein: An important part of cells that are responsible for the structure, function, and maintenance of your body and organs
Red blood cells (RBCs): Blood cells that carry oxygen from the lungs to all cells in the body
Red blood cell transfusion: A process that adds red blood cells into the bloodstream
Splenectomy: The removal of your spleen through surgery
Stem cell: All immature cells before they mature and are given a specific role
Symptom: A physical or mental sign of a condition or disease
Transfusions: Procedures that add parts of blood or whole blood into the bloodstream
Transfusion burden: How often you need to have red blood cell (RBC) transfusions