REBLOZYL® (luspatercept-aamt) logo

INDICATIONS (1 of 2)

REBLOZYL® (luspatercept-aamt) is a prescription medicine used to treat anemia (low red blood cells) in adults with myelodysplastic syndromes with ring sideroblasts (MDS-RS) or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) who need regular RBC transfusions and have not responded well to or cannot receive an erythropoiesis stimulating agent (ESA).

REBLOZYL is not for use as a substitute for RBC transfusions in people who need immediate treatment for anemia.

It is not known if REBLOZYL is safe or effective in children under 18 years of age.

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Hypothetical patient with anemia in myelodysplastic syndromes with ring sideroblasts (MDS-RS) Hypothetical patient with anemia in myelodysplastic syndromes with ring sideroblasts (MDS-RS)

About REBLOZYL in myelodysplastic syndromes with ring sideroblasts (MDS-RS)

About REBLOZYL in myelodysplastic syndromes with ring sideroblasts (MDS-RS)

Treating anemia is an important part of managing myelodysplastic syndromes (MDS). REBLOZYL is a treatment option that helps manage your anemia associated with lower-risk MDS.

What is REBLOZYL?

REBLOZYL is a prescription medicine used to treat anemia (low red blood cells) in adults with MDS-RS or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) who need regular red blood cell (RBC) transfusions and have not responded well to or cannot receive an erythropoiesis-stimulating agent (ESA).

REBLOZYL is not for use as a substitute for RBC transfusions in people who need immediate treatment for anemia.

It is not known if REBLOZYL is safe or effective in children. REBLOZYL may help lower the number of RBC transfusions you need.

REBLOZYL is called an erythroid maturation agent (EMA). It is the first and only EMA.

An EMA helps immature RBCs (called erythroid cells) develop and become mature, working RBCs. This may result in more healthy RBCs and improve anemia.

Immature red blood cell developing into a mature red blood cell

How does REBLOZYL work?

It’s important that you learn about how REBLOZYL works before starting treatment. This can help you better understand why your doctor prescribed REBLOZYL. It can also make you feel more confident when talking with your healthcare team.

  • REBLOZYL works by developing more mature, working RBCs
  • REBLOZYL allows more immature cells to mature and work the right way. As patients received REBLOZYL, the quality of RBCs improved and the amount of hemoglobin (Hgb) increased

This means that there are more mature RBCs in the bloodstream.

Bloodstream

Starting a different treatment can be a hopeful time. It might also bring some anxiety about what happens next, and there can be a lot to learn when you get started. To help with this time of change, there are resources and support to help you get the most from your treatment.