Resources for people with MDS and their loved ones

Get tools to help you navigate the REBLOZYL journey
with confidence.

Photo of a hypothetical patient dishing up food for two loved ones sitting down at the dining table

Downloadable treatment support tools

Below, you'll find helpful resources you can download to learn more about myelodysplastic syndromes (MDS). You'll also find links to websites with additional support and information.

Treatment Tracker brochure

Treatment Tracker

Keeping track of your symptoms and hemoglobin levels in one place can help your healthcare team stay informed and help you see how you are advancing toward your goals.

Patient brochure

REBLOZYL Patient Brochure

The patient brochure provides you with everything you need to know about starting treatment for MDS-related anemia with REBLOZYL.

Patient Spanish brochure

REBLOZYL Patient Brochure (en Español)

Todo lo que necesita saber sobre el inicio del tratamiento de la anemia relacionada con sі́ndromes mielodisplàsicos con REBLOZYL.

Doctor Discussion Guide

Doctor Discussion Guide

Stronger conversations can lead to better treatment outcomes, and we want to set you up to have the best conversations with your healthcare team.

Education brochure

MDS Education Brochure

The MDS education brochure is designed to help you and your loved ones have a deeper understanding of MDS, MDS-related anemia, and the different approaches to treatment.

Education Spanish brochure

MDS Education Brochure (en Español)

El folleto informativo sobre el MDS está diseñado para ayudarle a usted y a sus seres queridos a comprender mejor el MDS, la anemia relacionada con el MDS y los diferentes enfoques de tratamiento.

I have to happily say that, since I've been on Reblozyl, I've not required any blood transfusions. Stated by Teri, a real Reblozyl patient. Individual results may vary.

Hear from someone who has managed MDS-related anemia with REBLOZYL.

Share to Inspire - Because your story can help inspire another

If you’re being treated with REBLOZYL, we’d love to hear your story. Your story could help other patients and caregivers along their journey. Visit ShareToInspire.com or call us toll-free at 1-855-436-5866.

Places to explore more information about MDS

The following organizations provide disease education, additional support, and expert opinions. This list of independent organizations is provided as an additional resource for obtaining information related to MDS and does not indicate endorsement by Bristol Myers Squibb of an organization or its communications.

Select each organization's logo below to visit their homepage and learn more.

Aplastic Anemia & MDS International Foundation logo
American Cancer Society® logo
Cancer Support Community logo
Health Tree Foundation logo
Leukemia & Lymphoma Society logo
Myelodysplastic Syndromes Foundation logo
National Cancer Institute logo
A caregiver advocate speaking on behalf of a patient to their doctor

Caregivers are the best advocates for action

A caregiver's support can make all the difference in their loved one's treatment journey. Learn more about MDS-related anemia to feel prepared for the road ahead.

Your REBLOZYL® (luspatercept-aamt) Connection™

Get connected to receive ongoing resources

Your REBLOZYL Connection™ is an educational program designed to help you understand treatment with REBLOZYL and provide resources so you can take a more active role in your care.

Important Facts About REBLOZYL®
(luspatercept-aamt)

This is a summary of important information that you need to know about REBLOZYL. Your healthcare team can work with you to help answer any questions you may have about this medication. Keep this information in a safe place so you can refer to it before and during your treatment.

Look out for the following icons as you read:

Chat

Talk to your healthcare team

Call your healthcare provider

Call a healthcare provider right away

Information

Helpful information to remember

What is REBLOZYL?

Prescription medicine injection

REBLOZYL is a prescription medicine for injection, and is used to treat anemia (low red blood cells) in adults with:

β (beta) thalassemia who need regular red blood cell (RBC) transfusions.

MDS who may need regular RBC transfusions and have never received another type of medicine called an erythropoiesis stimulating agent (ESA).

MDS: myelodysplastic syndromes

MDS-RS or MDS/MPN-RS-T who need 2 or more RBC units over 8 weeks and have not responded well to an ESA.

MDS-RS:  myelodysplastic syndromes with ring sideroblasts

MDS/MPN-RS-T:  myelodysplastic syndromes or myeloproliferative neoplasms with ring sideroblasts and thrombocytosis

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REBLOZYL is not a substitute for RBC transfusions in people who need immediate treatment for anemia.

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It is not known if REBLOZYL is safe or effective in children under 18 years of age.

What should I discuss with my healthcare team before starting treatment?

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Talk to your healthcare team about all of your health problems and risk factors, including if you:

  • have or have had blood clots
  • take hormone replacement therapy or birth control pills (oral contraceptives)
  • have had your spleen removed (splenectomy)
  • smoke
  • have or have had high blood pressure (hypertension)
  • have a history of extramedullary hematopoietic (EMH) masses
  • have or have had enlarged spleen or liver
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Talk to your healthcare team about all the medicines you are taking, including:

  • prescription medicines
  • over-the-counter medicines
  • vitamins
  • herbal supplements

These are not all the topics you should discuss with your healthcare team. Ask your healthcare team about anything you may be unsure about before starting treatment.

What should I discuss with my healthcare team about pregnancy, birth control, and breastfeeding?

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Talk to your healthcare team if:

unborn baby

You are pregnant or plan to become pregnant — REBLOZYL may harm your unborn baby

If you are able to become pregnant, your healthcare team should do a pregnancy test before you start receiving REBLOZYL. You should use an effective method of birth control during treatment and for at least 3 months after your last dose of REBLOZYL. Talk to your healthcare team about birth control methods that you can use with REBLOZYL.

Call your healthcare provider

Call your healthcare provider right away if you become pregnant or think you are pregnant during treatment with REBLOZYL.

REBLOZYL may affect your ability to become pregnant. Talk to your healthcare team if fertility problems are a concern for you.

Breastfeeding

You are breastfeeding or plan to breastfeed

Do not breastfeed during treatment and for 3 months after the last dose of REBLOZYL. It is not known if REBLOZYL passes into your breast milk. Talk to your healthcare team about the best way to feed your baby during this time.

What are the serious side effects of REBLOZYL?

A serious side effect is a side effect that can sometimes become life-threatening and can lead to death. They may happen any time during treatment or even after your treatment has ended. You may experience more than one side effect at the same time.

Blood clots (thrombosis/thromboembolism) — Blood clots in the arteries, veins, brain, and lungs have happened in people with β-thalassemia during treatment with REBLOZYL. The risk of blood clots may be higher in people who have had their spleen removed or who take hormone replacement therapy or birth control pills.

Call your healthcare provider

Call your healthcare provider or get medical help right away if you have any of these symptoms:

  • chest pain
  • trouble breathing or shortness of breath
  • pain in your leg, with or without swelling
  • a cold or pale arm or leg
  • sudden numbness or weakness that is short-term or continues to happen over a long period of time, especially on one side of the body
  • severe headache or confusion
  • sudden problems with vision, speech, or balance (such as trouble speaking, difficulty walking, or dizziness)

High blood pressure (hypertension) — REBLOZYL may cause an increase in your blood pressure. Your healthcare provider will check your blood pressure before you receive your REBLOZYL dose. Your healthcare provider may prescribe you medicine to treat high blood pressure or increase the dose of medicine you already take to treat high blood pressure, if you develop high blood pressure during treatment with REBLOZYL.

Extramedullary Hematopoietic (EMH) Masses — EMH masses have happened in people with beta thalassemia during treatment with REBLOZYL. You may have a higher risk for developing EMH masses if you have a history of EMH masses, have had your spleen removed, have or have had enlarged spleen or liver, or have low hemoglobin levels. Your healthcare provider will monitor you before you start and during treatment with REBLOZYL. Call your healthcare provider or get medical help right away if you get any of these symptoms:

  • severe pain in the back
  • numbness or weakness or loss of voluntary movement in feet, legs, hands or arms
  • loss of bowel and bladder control

What are the most common side effects of REBLOZYL?

The most common side effects of REBLOZYL include:

  • tiredness
  • headache
  • back, joint, muscle, or bone pain
  • joint pain
  • dizziness
  • nausea
  • diarrhea
  • cough
  • stomach (abdominal) pain
  • trouble breathing
  • swelling of your hands, legs, or feet
  • high blood pressure
  • allergic reactions

These are not all of the possible side effects.

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Talk to your healthcare team for more information about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.

How will I receive REBLOZYL?

Prescription medicine injection

REBLOZYL is given as a subcutaneous injection (under your skin) in the upper arm, thigh, or stomach by your healthcare provider. The recommended starting dose of REBLOZYL is 1 mg/kg, once every 3 weeks. Work with your healthcare team to determine the right treatment plan for you.

REBLOZYL is a type of medicine called an erythroid maturation agent (EMA), and comes in single-dose vials that need to be prepared for injection by a healthcare professional.

Active ingredients: luspatercept-aamt

Inactive ingredients: citric acid monohydrate, polysorbate 80, sucrose, and tri-sodium citrate dihydrate

Tube blood

Before each REBLOZYL injection, your healthcare provider will do a blood test to check your hemoglobin and review your transfusion record to see how your anemia is responding to REBLOZYL. Your healthcare provider may adjust your dose or stop treatment depending on how you respond to REBLOZYL.

What if I delayed or missed a dose?

Call your healthcare provider

Call your healthcare provider as soon as possible to reschedule your next appointment if you delayed or missed a dose. Your healthcare provider will give your dose of REBLOZYL as soon as possible. Your treatment with REBLOZYL will continue as prescribed, with at least 3 weeks between doses.

Information

For more information, please see Full Prescribing Information and Medication Guide for REBLOZYL.Talk to your healthcare team for more information about this medication.

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This website is intended for U.S. residents 18 years of age or older.

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REBLOZYL® is a trademark of Celgene Corporation, a Bristol Myers Squibb company.

Access Support® and Your REBLOZYL Connection™ are trademarks of Bristol-Myers Squibb Company.

REBLOZYL® is licensed from Merck & Co. Inc., Rahway, NJ, USA and its affiliates.

© 2025 Bristol-Myers Squibb Company.

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