What important questions should I ask my healthcare team when receiving REBLOZYL?

One of the best ways to learn about your treatment with REBLOZYL is to talk to your healthcare team. Speaking with your healthcare provider or healthcare team can help make you feel more informed and comfortable. Below are some questions that you may want to ask.

  • Why am I being prescribed REBLOZYL?
  • What are the most important things I need to know about REBLOZYL?
  • Where and how do I receive REBLOZYL?
  • What should I expect while receiving REBLOZYL?
  • What are the most common side effects? And what should I do if I experience one?
  • Are there things that I should not do while receiving REBLOZYL?
  • How and where will my hemoglobin levels be tested prior to dosing?
  • How often should I come in for follow-up visits while receiving REBLOZYL?
  • How long will it take for REBLOZYL to start working? How will I know if it’s working?
  • What dose of REBLOZYL will I be receiving?
  • What if I miss a dose of REBLOZYL?
  • Will my dose of REBLOZYL stay the same?
  • Are there any medications I can’t take while I’m receiving REBLOZYL?
  • How will REBLOZYL affect the course of my disease?
  • What are the pros and cons of receiving REBLOZYL?

Resources for people with β-thalassemia

The following organizations provide disease education, additional support, and expert opinions. Inclusion on this list does not indicate endorsement by Bristol Myers Squibb company of an organization or its communications.

*This list of independent organizations is provided as an additional resource for obtaining information.

Celgene Patient Support®

Celgene Patient Support Logo

Learn about financial help for REBLOZYL

At Celgene Patient Support®, we care about making sure you get the help you need to start your treatment. Our Specialists are here to help you and your loved ones understand the programs and services that may be available to you.

Programs that help with the cost of REBLOZYL differ by the type of insurance you have. Even if you don’t have insurance or enough coverage to pay for your medicine, financial help may be available.

Financial assistance

There are programs and organizations that may help pay for REBLOZYL, depending on your insurance situation.

Celgene Commercial Co-pay Program

Co-pay responsibility for REBLOZYL is reduced to $0 (subject to annual benefit limits) for eligible patients with commercial or private insurance (including healthcare exchanges).*

Celgene Patient Assistance Program (PAP)

REBLOZYL may be available at no cost for qualified patients who are uninsured or underinsured.

If you are unable to afford your medication (including patients with Medicare, Medicaid, or other government-sponsored insurance), you may be able to receive help from independent third-party organizations.

Enrolling in Celgene Patient Support®

Email us at patientsupport@celgene.com
or fax to 1-800-822-2496

For more information on Celgene Patient Support®

Call us at 1-800-931-8691,
Monday – Friday 8AM – 8PM ET
(translation services available)

*Other eligibility requirements and restrictions apply. Please see full Terms and Conditions on the Celgene Patient Support® website.

Patients must meet specified financial and insurance eligibility requirements to qualify for assistance. Please see Eligibility Requirements on the Celgene Patient Support® website.

Financial and medical eligibility requirements vary by organization.

Glossary

Anemia: Low red blood cell count

Beta globin: A protein building block of hemoglobin

Blood pressure: The force of circulating blood on the walls of blood vessels

Bone marrow: The soft interior of the bones where new blood cells are created

Chelating agent: A chemical compound used to remove toxic metals from the body

Erythroid cell: An immature red blood cell

Erythroid maturation agent: Treatment that helps young cells become mature cells

Erythropoiesis: The formation of red blood cells in blood-forming tissue within the bone marrow

Erythropoiesis-stimulating agent: A manufactured growth hormone that helps the body produce more immature red blood cells

Hemoglobin: Oxygen-carrying protein found in red blood cells

Hydroxyurea: A type of medicine used to treat certain cancers

Immunosuppressant: An agent that decreases the body’s immune response

Ineffective erythropoiesis: The inability of oxygen-carrying red blood cells to leave the bone marrow

Ischemic stroke: The most common type of stroke, caused by a blood clot that blocks a blood vessel in the brain

Median: A statistics term. The middle of a range of numbers

Mutation: An abnormal change within a gene

Placebo: An inactive substance that looks the same as, and is given the same way as, an active drug or treatment being tested

Red blood cells (RBCs): Blood cells that carry oxygen from the lungs to all cells in the body

Red blood cell transfusion: A process that adds red blood cells into the bloodstream

Subcutaneous: Under the skin

Thromboembolic event: Formation of a clot in a vein or artery that breaks loose and is carried by the blood to block a blood vessel

Thrombosis: Formation of a blood clot

Uric acid: A chemical created when the body breaks down certain substances made by the body and found in some foods and drinks, and is removed from the body by the kidneys. Too much uric acid in your body can cause you to become sick

What is REBLOZYL® (luspatercept-aamt)?

REBLOZYL is a prescription medicine used to treat anemia (low red blood cells) in adults with:

  • beta thalassemia who need regular red blood cell (RBC) transfusions.
  • myelodysplastic syndromes with ring sideroblasts (MDS-RS) or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) who need regular RBC transfusions and have not responded well to or cannot receive an erythropoiesis stimulating agent (ESA).

REBLOZYL is a prescription medicine used to treat anemia (low red blood cells) in adults with myelodysplastic syndromes with ring sideroblasts (MDS-RS) or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) who need regular RBC transfusions and have not responded well to or cannot receive an erythropoiesis stimulating agent (ESA).

REBLOZYL is a prescription medicine used to treat anemia (low red blood cells) in adults with beta thalassemia who need regular red blood cell (RBC) transfusions.

REBLOZYL is not for use as a substitute for RBC transfusions in people who need immediate treatment for anemia. It is not known if REBLOZYL is safe or effective in children.

Before receiving REBLOZYL, tell your healthcare provider about all of your medical conditions, including if you:

  • have or have had blood clots
  • have or have had high blood pressure (hypertension)
  • take hormone replacement therapy or birth control pills (oral contraceptives)
  • have had your spleen removed (splenectomy)
  • smoke
  • are pregnant or plan to become pregnant. REBLOZYL may harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with REBLOZYL.
  • Females who are able to become pregnant:

    • Your healthcare provider should do a pregnancy test before you start treatment with REBLOZYL.
    • You should use effective birth control (contraception) during treatment with REBLOZYL and for at least 3 months after the last dose.
  • are breastfeeding or plan to breastfeed. It is not known if REBLOZYL passes into your breast milk.
    • Do not breastfeed during treatment with REBLOZYL and for 3 months after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of REBLOZYL?

REBLOZYL may cause serious side effects, including:

  • Blood clots. Blood clots in the arteries, veins, brain, and lungs have happened in people with beta thalassemia during treatment with REBLOZYL. The risk of blood clots may be higher in people who have had their spleen removed or who take hormone replacement therapy or birth control (oral contraceptives). Call your healthcare provider or get medical help right away if you have any of these symptoms:
    • chest pain
    • trouble breathing or shortness of breath
    • pain in your leg, with or without swelling
    • a cold or pale arm or leg
    • sudden numbness or weakness that are both short-term or continue to happen over a long period of time, especially on one side of the body
    • severe headache or confusion
    • sudden problems with vision, speech, or balance (such as trouble speaking, difficulty walking, or dizziness)
  • High blood pressure. REBLOZYL may cause an increase in your blood pressure. Your healthcare provider will check your blood pressure before you receive your REBLOZYL dose. Your healthcare provider may prescribe you medicine to treat high blood pressure or increase the dose of medicine you already take to treat high blood pressure, if you develop high blood pressure during treatment with REBLOZYL.

The most common side effects of REBLOZYL include:

  • tiredness
  • headache
  • muscle or bone pain
  • joint pain (arthralgia)
  • dizziness
  • nausea
  • diarrhea
  • cough
  • stomach (abdominal) pain
  • trouble breathing
  • allergic reactions

REBLOZYL may cause fertility problems in females. This could affect your ability to become pregnant. Talk to your healthcare provider if this is a concern for you.

These are not all of the possible side effects of REBLOZYL. Call your doctor for medical advice about side effects. You are encouraged to report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information and Patient Information for REBLOZYL.