REBLOZYL® (luspatercept-aamt) is a prescription medicine used to treat anemia (low red blood cells) without previous erythropoiesis stimulating agent use (ESA-naïve) in adult patients with very low- to intermediate-risk myelodysplastic syndromes (MDS) who may require regular red blood cell (RBC) transfusions.
It is not known if REBLOZYL is safe or effective in children under 18 years of age.
This website is best viewed using the horizontal display on your tablet device.
This website is best viewed using the vertical display on your mobile device.
Stay connected to the
support you need
Your REBLOZYL Connection is an educational
program designed to help you understand
your treatment with REBLOZYL, and provide
resources that allow you to be more
active role with your care.
SHARE TO INSPIRE
Because your story can
help inspire another
If you’re being treated with
REBLOZYL, sharing your story could
help other patients and caregivers.
Visit ShareToInspire.com or call us
toll-free at 1-855-436-5866.
MDS Glossary
Anemia: Low red blood cell (RBC) count
Blood cells: Blood cells begin as stem cells in the bone marrow. Stem cells grow and mature into different types of cells: red blood cells, white blood cells, and platelets. After the cells have matured in the bone marrow, the red blood cells, white blood cells, and platelets enter the bloodstream
Blood pressure: The force of circulating blood on the walls of blood vessels
Bone marrow: The soft interior of the bones where new blood cells are created
Chemotherapy: A type of treatment that kills or stops the growth of abnormal cells in the body. It is often used to treat cancer
Cytopenia: Lower than normal number of blood cells
DNA: The information inside your cells that is responsible for how you look and behave
Erythroid cells: An immature red blood cell
Erythroid maturation agent (EMA): Treatment that helps red blood cells to mature
Erythropoiesis-stimulating agent (ESA): A manufactured erythropoietin given to people to help with anemia
Erythropoietin: A natural growth hormone produced by the kidneys that tells the body to make more immature red blood cells
Hematocrit: A measure of the body's red blood cells
Hemoglobin (Hgb): Oxygen-carrying protein found in red blood cells
Hormone: A chemical made by your body that travels in the bloodstream to send messages throughout your body
Immunomodulator: A type of medicine that changes part of the immune system
Immunosuppressive therapy: A type of treatment that decreases the body’s immune response
Immunotherapy: A type of treatment that modifies your immune system to help the body fight cancer
Kilogram (kg): A unit for measuring your weight. One kg is 2.2 pounds
Lower-risk: A lower chance of your MDS progressing to a more serious condition
Milligram (mg): A unit for measuring weight
mg/kg: The dose of your medication based on your body weight
Mutation: An abnormal change within a gene
MDS/MPN-RS-T: Abbreviation for myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis. It is a rare form of MDS in which there are a high number of platelets in the blood and the immature red blood cells contain ring sideroblasts
Myelodysplastic syndromes (MDS): MDS are a group of disorders in which the bone marrow does not make enough healthy blood cells
Myelodysplastic syndromes with ring sideroblasts (MDS-RS): A type of MDS where a certain number of immature red blood cells in your bone marrow are ring sideroblasts
Neutropenia: Lower than normal amount of neutrophils, a type of white blood cell
Placebo: An inactive substance that looks the same as, and is given the same way as, an active drug or treatment being tested
Platelets: A type of blood cell that helps with clotting
Red blood cells (RBCs): Blood cells that carry oxygen from the lungs to all cells in the body
Red blood cell transfusion: A process that adds red blood cells into the bloodstream
Ring sideroblasts (RS): Cells containing rings of iron deposits
Risk level: Your risk level is a score given by your healthcare team. Your risk level helps them understand the chances of your MDS progressing to a more serious condition. Risk level scores can range from “very low” to “very high”
Serum: The clear liquid part of the blood that remains after blood cells and clotting proteins have been removed
SF3B1: Splicing Factor 3B Subunit 1 (SF3B1) is a gene that can have mutations as part of your MDS. This mutation can be tested for as a part of your MDS diagnosis
Stem cell: All immature cells before they mature and develop a specific role
Stem cell transplant: A type of treatment that replaces your abnormal cells with healthy stem cells from a donor
Symptom: A physical or mental sign of a condition or disease
Thrombocytopenia: Lower than normal number of platelets in the blood
Transfusions: Procedures that add parts of blood or whole blood into the bloodstream
Transfusion burden: How often you need to have red blood cell (RBC) transfusions
White blood cells (WBCs): Blood cells that help the body fight infection as part of the body’s immune system