REBLOZYL® (luspatercept-aamt) logo
Now approved for earlier treatment of MDS-related anemia badge

INDICATIONS (1 of 3)

REBLOZYL® (luspatercept-aamt) is a prescription medicine used to treat anemia (low red blood cells) without previous erythropoiesis stimulating agent use (ESA-naïve) in adult patients with very low- to intermediate-risk myelodysplastic syndromes (MDS) who may require regular red blood cell (RBC) transfusions.

It is not known if REBLOZYL is safe or effective in children under 18 years of age.

Now approved for earlier treatment of MDS-related anemia badge

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Hypothetical patient with anemia in myelodysplastic syndromes with ring sideroblasts (MDS-RS)
Hypothetical patient with anemia in myelodysplastic syndromes with ring sideroblasts (MDS-RS)

Frequently asked questions about REBLOZYL and myelodysplastic syndromes (MDS)

REBLOZYL is a prescription medicine for injection, and is used to treat anemia (low red blood cells) in adults with:

  • MDS who may need regular red blood cell (RBC) transfusions and have never received another type of medicine called an erythropoiesis stimulating agent (ESA).
  • MDS-RS or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) who need 2 or more RBC units over 8 weeks and have not responded well to an ESA.

Learn more about how REBLOZYL works

REBLOZYL is an injection that could help lower the number of transfusions needed. REBLOZYL is not a substitute for red blood cell (RBC) transfusions in people who need immediate treatment for anemia.

It is not known if REBLOZYL is safe or effective in children under 18 years of age.

Learn more important facts about REBLOZYL

REBLOZYL is an injection given under your skin once every 3 weeks by your healthcare team at their office.

  • Given in your upper arm, thigh, or stomach
  • Needles used for injections that go under your skin are smaller than those used for injections that go into your muscle, such as those used for most vaccines

Learn more about how REBLOZYL works

REBLOZYL is an injection given under your skin by your healthcare team at their office. You will receive a REBLOZYL injection once every 3 weeks in your doctor’s office. You can receive REBLOZYL for as long as your doctor finds it is working for you and for as long as you are able to handle any side effects that may occur.

Learn more about what to expect with REBLOZYL

REBLOZYL has a well-known safety profile. It is important to know the side effects of any medicine you are taking. The most common side effects of REBLOZYL include:

  • tiredness
  • headache
  • back, joint, muscle, or bone pain
  • joint pain
  • dizziness
  • nausea
  • diarrhea
  • cough
  • stomach (abdominal) pain
  • trouble breathing
  • swelling of your hands, legs, or feet
  • high blood pressure
  • allergic reactions

These are not all of the possible side effects.

Learn more about the effects of REBLOZYL

Before each REBLOZYL injection, your doctor will do a blood test in their office to check your Hgb levels.

Learn more about starting on REBLOZYL

You will receive a REBLOZYL injection once every 3 weeks in your doctor’s office. If your scheduled REBLOZYL dose is delayed or missed, call your healthcare team as soon as possible to reschedule your next appointment.

Learn more about what to expect with REBLOZYL

Responses to REBLOZYL will vary from person to person. You and your healthcare team will track your response to treatment. While receiving REBLOZYL, you and your doctor will work together to reduce the number of transfusions.

Learn more about what to expect with REBLOZYL

People receiving REBLOZYL start on 1 milligram (mg)/kilogram (kg), once every 3 weeks. Your dose may go up. Some people need 1.33 mg/kg or 1.75 mg/kg, once every 3 weeks. You and your doctor can work together to see what REBLOZYL dose works for you.

Learn more about what to expect with REBLOZYL

If your scheduled REBLOZYL dose is delayed or missed, call your healthcare team as soon as possible to reschedule your next appointment. Your doctor will give you your dose of REBLOZYL as soon as possible.

Learn more about what to expect with REBLOZYL

People receiving REBLOZYL start on 1 milligram (mg)/kilogram (kg), once every 3 weeks. Your dose may go up. Some people need 1.33 mg/kg or 1.75 mg/kg, once every 3 weeks. You and your doctor can work together to see what REBLOZYL dose works for you.

Learn more about REBLOZYL dosing

Talk with your doctor before starting REBLOZYL about any other medications you may be taking. They will help determine whether it’s safe for you to start treatment with REBLOZYL.

Learn more about starting REBLOZYL

REBLOZYL is an injection that may help lower the number of red blood cell (RBC) transfusions needed and raise hemoglobin levels for adult patients with:

  • MDS who may need regular red RBC transfusions and have never received another type of medicine called an erythropoiesis stimulating agent (ESA)
  • MDS-RS or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) who need 2 or more RBC units over 8 weeks and have not responded well to an ESA

Learn more about how REBLOZYL has helped people with anemia in MDS

For adult patients with myelodysplastic syndromes (MDS), myelodysplastic syndromes with ring sideroblasts (MDS-RS), or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T), REBLOZYL can help manage anemia and may help reduce the number of transfusions you may need over time.

REBLOZYL has a well-known safety profile. It is important to know the side effects of any medicine you are taking. Be sure to talk with your healthcare team about REBLOZYL side effects. Keep in mind, side effects can vary from person to person, so it’s important to understand what to expect during REBLOZYL treatment.

Learn more about the results from the REBLOZYL study

Bristol Myers Squibb is committed to helping patients gain access to their prescribed BMS medications. BMS Access Support® can provide patient access and reimbursement assistance. BMS Access Support provides resources to help patients understand their insurance coverage.

Learn more about BMS Access Support®

REBLOZYL is not a form of chemotherapy. It is a treatment that helps manage the anemia that is associated with lower-risk myelodysplastic syndromes (MDS).

REBLOZYL is called an erythroid maturation agent (EMA). EMAs help immature red blood cells (RBCs) (called erythroid cells) develop and become mature, working RBCs.

Learn more about REBLOZYL